Introduction: Corona Virus Disease 19 (COVID-19) has been associated with high mortality and morbidity. Cytokines play a central role in determining the immunity against any infection including COVID-19. The inherent presence of polymorphism determine the production of cytokines, which in turn determines the susceptibility or resistance to COVID-19 infection.  Among cytokines, Interferon gamma (IFN γ) plays a central role in activating inherent immunity and presence of polymorphism would derail its activity. The aim of the present study to evaluate the Corona Virus Disease 19 and its association with Interferon γ Gene +874 A/T Polymorphism.

Materials and Methods: The blood samples were collected from 100 COVID-19 cases and 100 controls after taking informed consent. The DNA was extracted, and amplification refractory mutation system (ARMS PCR) was performed to analyze the presence of genotype along with allele frequency. Statistical analysis was performed with application of chi square tests, Shapiro-Wilk tests and Mann-Whitney tests.

Results: The study found significant association between the AT heterozygous genotype with COVID-19 (p=0.0006). We also found association of AT heterozygous polymorphism and thyroid disorder more in mortality cases (p=0.040). We could not find any correlation between the association of comorbidities and polymorphism in relation with infection.

Conclusion: The study found that Corona Virus Disease 19 has been found to be associated with heterozygous interferon γ Gene +874A/T polymorphism. It has also been found to be associated with hypothyroidism. Precautions have to be taken to prevent infection in the susceptible population and diligent monitoring to be undertaken to improve the outcome of the infection in the individuals proven to be more susceptible.