Snakebites represent a serious worldwide public health and social problem because of their high frequency, morbi-mortality, and sequelae left of victims.The neutralizing potency of methanol extract of Jatrophacurcaswere found to validate traditional claims of useful of plant in management of snakebites. In case of study the total of (43) mice were used to detoxify the effect of Jatrophacurcaswere equal value of venom were administered to all groups of mice. The results indicated that the extract caused reduction in the induced mice and directly or indirectly detoxified the snake venoms used by 3.33 - 30%, thus to restored the effect of snake venom (i.e. neutralization of the venom) the extract exhibited an LD₅₀ of 0.764 mg/kg. This study shows that Jatrophacurcas is effective in pathological of puff adder venom, and produce some scientific basis in the management of toxins produced by the snakebites.The outcome of this research shows that Jatrophacurcas has great potential for the treatment of the local effect produced by puff adder and some snake venoms. Thus the methanolic extract of Jatrophacurcus have substance/components that can inhibit or inactivates the toxins present in the venom produced by snake (puff adder) as well as activity indirectly upon endogenous mediators. the outcome of this research shows that Jatrophacurcas has great potential for the treatment of the local effect produced by puff adder and some snake venoms. Thus the methanolic extract of Jatrophacurcus have substance/components that can inhibit or inactivates the toxins present in the venom produced by snake (puff adder) as well as activity indirectly upon endogenous mediators.