Objective: Coronavirus (cov) disease soon and severely challenged the health community in many parts of the world. This infectious disease was produced by the newly discovered SARS-Cov-2 called Covid-19.

Materials and methods: In this study, all articles related to the effect of SARS, MERS, and cov-19 viruses on the female reproductive system from 2003 to 2021 were reviewed.

Results: The coronavirus enters the host cell by binding to the enzyme that is most abundant in the host lung. The corona or spike (S) protein of this virus is the main tool for binding to the receptor in the host cell membrane and facility the entrance of cov into the target cells. This receptor is the Angiotensin-Converting Enzyme-2 (ACE2), but the high expression of this receptor can be a mystery to increase infection in host cells. The overexpression of ACE2 in different tissues has a close connection to the severity of this viral infection. Infection in the female reproductive system requires more attention because it may affect the generation and future progeny by damaged gametes.

Conclusion: The purpose of this review was to investigate current cov knowledge by highlighting current signs of progress in the reproductive tract. The existing evidence proposes that ACE2 is widely expressed in the reproductive tract includes: ovary, uterus, vagina, and placenta. Can coronavirus affect the female reproductive functions via disturbing the modulation and regulating ACE2 hemostasis? Is the role of sex hormones in this process significant? The purpose of this review is to answer these questions.