Background: Breast cancer is among the most prevalent forms of cancer worldwide. Surgical intervention is the primary treatment. A comprehensive understanding of the impact of the radical and reconstructive stages of this approach is significant for the management of this condition.

Objective: The purpose of this study is to make a comparison between the quality of life of patients who underwent mastectomy and non-flapped breast reconstructions for cancer.

Material and methods: The study included 90 patients diagnosed with breast cancer 0–IIA st. T1–2N0M0. The age of patients ranged from 30 to 65 years, with an average age of 49.76 ± 8.54 years. Patients were divided into three groups of 30 women, depending on the type of surgical treatment of the tumour and breast reconstruction: The first group underwent Madden surgery with a subsectoral expander installation and subsequent replacement with a silicone endoprosthesis; the second group underwent Madden surgery with prepectoral expander installation, staged lipofilling, and replacement with silicone endoprosthesis; and the third group underwent radical subcutaneous mastectomy with one-stage prepectoral breast reconstruction. The quality of life of the patients was assessed using the Breast-Q 2.0 questionnaire, which has been validated in the Russian Federation. The questionnaire is divided into three sections: 1) psychosocial well-being of the patients; 2) physical well-being of the breasts; and 3) sexual well-being of the patients. The final score is recalculated using the RASA system, ranging from 0 (worst score) to 100 (best score).

Discussion and conclusions: The study shows that subcutaneous mastectomy with one-stage prepectoral breast reconstruction is a viable surgical intervention. This is because it improves patients' quality of life during rehabilitation, particularly in psychosocial, physical and sexual well-being. This is due to the technique, which restores all the breast's components and reduces the rehabilitation period.