Medicinal plants play an important role in disease treatment and have less & controllable side effects. Medicinal plants are available sources of very effective matters which are similar to materials used in the metabolism of the human body and therefore can be absorbed easily. Boswellia affects estrogen secretion and has been used as ovarian cancer drug for a long time. Boswellia destroys cancer cells in ovary as a cancer drug. This study was carried out to investigate the effects of boswellia’s hydroalcoholic extract on ovarian histology of mice. Mice were divided into five groups including control, placebo, and three experimental groups with 10 members in each group. Control group did not receive any drug and experimental groups received intraperitoneal injections of 50, 100 and 200 mg/kg of the extract for 20 days every other day. Ovarian tissue slides were prepared and studied using light microscopy. Obtained results were analyzed using SPSS program and one-way analysis of variance. Means were compared using Duncan test at 5% probability level. According to results, boswellia reduced follicles in doses of 100 and 200 mg/kg significantly but 50 mg/kg group showed no significant difference from the control group. Significant reduction in the number of corpus luteum was observed in experimental groups. According to the results, boswellia extract can affect female mice reproduction system dose dependently and can reduce fertility of female sex.

 

Keywords: Boswellia, Ovarian histology, Follicle, Corpus luteum, Mice