Background: The most serious and common adverse side effect associated with anticoagulant is increased risk of bleeding, both non-major and major bleeding events. Risk of bleeding is dependent on the class of anticoagulant agent used, patient's age, and pre-existing health conditions. Drugs derived from plants as green medicine is believed to be safe and dependable, compared with costly synthetic drugs that have adverse effects. Honey has been used since ancient times for its nutritional and therapeutic value, Acacia honey is available worldwide and it is inexpensive in compare to anti-thrombotic and thrombolytic agent. And has anticoagulant activity for treatment these problems.

Materials and Methods: In this study 100 normal blood samples from normal individuals with age range (18-30) years, 50% male and 50% female. PT and APTT tests were done before adding acacia honey by mixture patient plasma with normal plasma (as controls) and after adding acacia honey with different concentrations (10% and 25%).

Results: the results were analyzed by using SPSS and showed that the acacia honey has a strong statistically significant (p= 0.000) in all concentrations in both PT and APTT tests.

Conclusion: this study approved that acacia honey has a strong anticoagulant effect; so acacia honey can be used as a supplementary anticoagulant agent to improve and/ or prevent thrombosis and cardiovascular diseases.

 

Keywords: Natural Acacia honey, Coagulation, PT and APTT, Sudanese healthy individuals

 

List of abbreviations: PT: Prothrombin Time; APTT: Activated Partial Thromboplastin Time; DVT: Deep Vein Thrombosis; PPP: Platelet poor plasma; BV: Blood Vessel; VWD: Von willebrand disease