This abstract is aimed at investigating the traditional claim that African ebony stem bark has hypoglycemic and hypolipidemic effects. Plant extraction was carried out using the standard method. Thirty (30) rats weighing between 90-140g were divided into 3 groups (A, B, and C) of 10 rats each, which were all acclimatized. Group A are treated diabetic rats (TDR); induced with alloxan and then given the plant extract, group B are non-treated diabetic rats (NTDR); induced with alloxan, but not treated with plant extract while group C is as normal control. Diabetes was induced in group A and B rats using 5% alloxan (150 mg/kg BW) intraperitoneal for 72 hours resulting in high glucose levels. A were treated with a 100 mg/Kg BW dose of extracts daily for 12 days. A glucometer was used to check the glucose level at 4 days intervals, until the last day using the glucose oxidase method. The result revealed that the weights of the diabetic rats decreased after the induction while it was the reverse in group A after treatment, while NTDR decreased continuously.  The glucose levels of the TDR and NTDR after induction increased. The values of the TDR decreased while that of the NTDR increased after 12 days of treatment. The lipid profile revealed that the value increased in NTDR, which shows a significant difference when compared with treated and control (p<0.05). Statistical analysis of the result using SPSS version 2.0 in which ANOVA and t-test yielded significant differences between the values of TDR and NTDR (p<0.05). The result, therefore, revealed the plant to be a potential hypoglycemic and hypolipidemic agent for the treatment of diabetes mellitus.

Keywords: Hypoglycemic, Hypolipidemic, Alloxan, Diabetes