Objective: To investigate the immunomodulatory effects  of Cyclea peltata leaf extract.

Methods: The fresh whole Cyclea peltata plants were collected from Kasaragod and Kannur areas of Kerala, India. The crude extracts of leaves were prepared using methanol and aqueous solvents and were used to investigate the antibacterial activity against Streptocococcus mutans, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoneae by well diffusion method, antioxidant by DPPH method and immunomodulatory study using Swiss albino rats.

Results: The extracts showed the presence of phytoconstituents like tannin, proteins, resins, carbohydrates, alkaloids and terpenoids. All the extracts showed varying degree of inhibitory potential against all the tested bacteria. Methanol extract of plant had higher inhibitory action against Pseudomonas aeruginosa and Streptococcus mutans.  While Staphylococcus aureus showed low sensitivity against aqueous extract of C. peltata. The body weight of the animals showed constant in the case of lower concentration of the drug (1 mg/kg), whereas at higher concentration, the animals showed reduced body weight, with more reduction in highest concentration. Similarly for the organs like liver, the higher dose showed increased mass of liver when compared to lower doses of the drug. The tested animals showed good immunomodulatory effect against the leaf extract.

Conclusions: The present investigation showed the effectiveness of crude extract of this plant against tested bacterial strains. This study further suggests the use of whole plant extract in treating disease caused by tested microbial organisms. As extracts showed good immunomodulatory effects the plant can be further experimented with active compound.