Bromodomain containing protein (BRD4) play a major role in the gene expression, both in normal cell and cancerous cell through direct interaction with acetylated lysine residue at the N- Terminal of histone tail with the help of transcription factors such as RELA, ER, P53. In healthy body, It promotes cell cycle regulation, cell growth and development and a help in serving as scaffold that control the recruitment of other transcription regulator to chromatin network which can finally modulate the transcription machinery itself but due to dysregulation of BRD4, lead to changes in macro molecular complexes of DNA and supporting gene expression and epigenetic regulation that contribution to pathogenesis of disease. It is very difficult to understand this protein due to its unclear mechanisms of action and poor selective toward its targets sites

 

Keywords: Bromodomain, Cancer, Transcription, Chromatin

 

Abbreviations: ER- Estrogen Receptor