The principle of this editorial to recapitulate what sources dissolution testing employed for safe and efficient generic drug dissolution profile, dissolution has been the subject of extreme and beneficial scientific advancement. The pharmaceutical manufacturing and the registration authorities’ downs spotlight on studies of drug dissolution. In-vitro dissolution testing act as a key role in FDA’s efforts to trim down the regulatory trouble along with avoidable human abstraction in generic drug development exclusive of jeopardize the drug attribute. Opportune dissolution profiles for water-insoluble medicine and immediate-release products, it may be sufficient using a single method dissolution testing, the test is termed as “drug release” mainly, for non-oral dosage forms, testing of physicochemical characteristics of the drug, formulation, especially testing of dissolution device and miscellaneous factors plays a critical role in dissolution profile, considered as rate-limiting step which can affect any drug profile, therefore we should regard this factor keenly on prior note.

 

Key words: Influential factors, Dissolution profile, Water insoluble drugs, Physicochemical properties, Product development, Dosage forms