Background: Episodes of the acute febrile illnesses increases day by day due to poor socioeconomic status in developing nations. Dengue and Chikungunya are emerged as important Arboviral and Alphaviral diseases respectively, with significant impact on the disease burden residing in these areas. Both the viruses, seems to have the hepato-toxic effect. Affiliation of liver in form of derangement in liver function tests is common and may include mild elevation in serum bilirubin, elevated Transaminases and derangement in serum albumin. present study focuses on the hepatic manifestations of the liver injury in dengue and chikungunya patients.

Study Design: A hospital based cross sectional study was conducted on patients attending the outpatient and inpatient departments, of medicine department at Shri Mahant Indresh hospital Dehradun. 161 cases (64 of dengue and 77 of chikungunya) were selected for the study, 20 cases were febrile but negative for both dengue and chikungunya.

Material and Methodology: After taking the ethical clearance from the ethical committee. Total number of 161 cases of acute febrile illnesses were included in the study. 5 ml of blood sample from each of them is collected in a sterile test tube. The blood samples are analyzed via RT-PCR technique at the central molecular research lab in Biochemistry department of SGRRIMHS and liver profile is analyzed at central clinical lab of the SMI hospital.

Result: Out of 161 febrile cases 64 cases were positive for dengue which is 39.75%, 77 cases were positive for chikungunya which is 47.82% rest 20 cases were febrile but negative for both dengue and chikungunya which is 12.43%. Liver enzymes were significantly raise (p<0.0001) in both males & females cases.

Conclusion: Dengue virus is more Hepatotoxic than Chikungunya.

Keywords: Acute febrile illnesses, Chikungunya, Dengue, Liver profile.

Abbreviations: RT-PCR - Real time Polymerase Chain Reaction.