Objective
The purpose of this study was to develop SML-FCN nano-lipid carriers to estimate as potentials of oral delivery system for poorly water soluble drugs. NLCs applied to chronomodulated pulsatile drug delivery system maintain the concentration level by releasing at the drug predetermined time interval and through management of asthma.
Method
The particle size analysis revealed all the formulations were within the nanometer range 150.0±2.4nm. Percentage of entrapment efficiency and drug loading were found to be 69.5±4.4 - 85.3±1.3 and 9.358±2.2-10.45±8.1, respectively. The SML-FCN NLCs optimized formulation showed spherical morphology with smooth surface under the transmission electron microscope (TEM), the crystalline characterization of the drug in NLC was investigated by X-ray diffraction and differential scanning calorimetry (DSC) .the ex-vivo permeation study showed in many folds increment in the SLM-FCN NLCs compared to powder SLM-FCN, pulsing plugs in-vivo drug released effectively in pre-determine time intervals 96.0±2.55.
Conclusion
The progression concludes to the chronomodulated programming pulsatile release was achieved with modified pulsing belayed plugged of salmeterol fluticasone propionate NLCs, formulation remarkably improved oralboivilability. I promising findings in these investigations suggest practicability the dosage form system can be taken after bedtime then will be delivered in the early morning which maintains the drug concentration throughout to manage asthma.
Keywords
Chronomodulated, Liposome’s, Salmeterol, Fluticasone propionate, Pulsing erodible layer.
Abbreviations:
SML- solometerol
FCN- fluticasone propionate
NLC- nano lipid carrier
