Diabetes mellitus (DM) is often linked to problems of various organ systems, including retinopathy, neuropathy, andnephropathy. In addition, patients have changes in kidney functions such as urea and creatinine levels. Vincamine(VK), a monoterpenoid indole alkaloid, has hypoglycemic and antioxidant effects. This study evaluated the effect ofvincamine on renal dysfunction in alloxan-induced male rats by measuring fasting blood glucose, serum urea andcreatinine levels. Rats were randomly randomized into the following groups: untreated-healthy, untreated-diabetes,vincamine-treated (20mg/kg) diabetics, vincamine-treated (40mg/kg) diabetics, on day 14, rats were sacrificed andblood for analysis gathered. Kidneys removed from animals were examined for weight and noted. Compared withthe untreated diabetic group, the 40 mg/kg vincamine dose resulted in a significant reduction in FBC. Compared tothe untreated diabetic group, rats treated with vincamine were found to have lower plasma creatinine levels andlower urea levels. In the vincamine 20mg/kg group, kidney weights were higher than in the vincamine 40mg/kggroup. As a result, vincamine may have a potential preventive effect against diabetes-related kidney problems,which would be attributed to its antioxidant activity.

Keywords: Diabetes mellitus, Renal size, Streptozosin, Creatinine, Urea