Background: The rapid spread of Corona virus disease (COVID-19) across globe coupled with non-availability of treatment has triggered worries worldwide. The purpose of this article objective is to analyze the Challenges and opportunities' to tackle COVID-19 spread in Ethiopia, East Africa

Method: Qualitative systematic review

Result: Among the known measures, regular hand-washing practice among communities and maintaining physical (social) distance according to health care professional recommendations is the best available option to control the spread of COVID-19. Currently, Ethiopia has a very low health care workforce (Medical Doctors, Health Officers, Nurses, and Midwives) density of about 0.96/1000 population, which is 5 times less than the minimum threshold of 4.45 per 1000 population set by the World Health Organization (WHO).

Mass use of public transportation, shortage of sanitation material including water, hiding suspected cases, lack of personal protective equipment for health care providers, presence of immune-compromised people are among the major driving factors making Ethiopia one of the challenged developing country in facing this unprecedented COVID-19 spread.

Conclusion: Among the known measures to reduce the transmission of COVID-19 regular hand washing practice is the rewarding and physical distance is a major challenge. Presence of a huge number of homelessness people, mass use of public transportation, the maximum size of uneducated people, overcrowding in cities and homes, shortage of sanitation material including water, hiding suspected cases, lack in availability of personal protective equipment for care providers, Presence of immune-compromised people are among the major driving factors make Ethiopia one of the challenged developing country during this pandemic spread. So solidarity and equitability with community lead participation are mandatory.