The study's purpose was to create a gliclazide bilayer tablet with bimodal drug release. The main objective of this study is to investigate potential of xanthan gum as a bioadhesive sustained release layer. Here, xanthan gum used with cross carmellose, cross povidone, and SSG. Swollen volume outside bioadhesion, dissolution kinetics, water absorption, and in vitro drug release were checked. A non-Ficki and diffusion-regulated release mechanism used to study dissolution kinetics after the first burst, leading to the Higuchi model (R² = 0.9913). All 3² full factorial designs were considered in the current study. The optimal disintegration time for the direct compression technique utilizing cross-povidone resulted in the immediate release formulation (IR3). According to the disintegration testing results, the time was 1³ seconds. In the formulation, the kind of polymers coupled with xanthan gum and the amount of polymer substituted with sodium cross-carmellose were considered independent variables. It was possible to adequately incorporate the mucilage into tablets while preserving high adhesiveness and sustained drug release by replacing only 20 % of the natural mucilage, such as xanthan gum, with cross-carmellose sodium.

Keywords: Bilayer tablet, Gliclazide, Factorial design, Bioadhesive layer, Bilayer drug release