This  study  was  carried  out  to  investigate  the  antibacterial  and  immunomodulatory  activities  of Bryophylumpinnatum. Both aqueous and ethanol solvents were used for extraction. Five bacteria strains including Staphylococcus aureus, Streptococcus pneumoniae, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa were obtained from the University of Benin Teaching Hospital and they were preliminarily identified using standard microbiological methods. Agar well diffusion method was used for the antibacterial activity.Wistarrat models for the study were purchased and acclimatized for a period of two weeks. The rats were divided into five groups and orally administered with the ethanol extract of the plant while one group served as control.  Antimicrobial  and  hematological  parameters  including  packed  cell  volume  (PCV), hemoglobin,  white  blood  cell  counts,  platelets  and  CD4count  were  assayed  using  standard methods.  Diameter of inhibition in aqueous extract ranged from 9.20±0.17-10.50±0.50mm and 9.30±0.33- 10.33±0.89mm against Escherichia coli and Staphylococcus aureusrespectively at 25-100mg/ml. In the ethanol extract, mean zone of inhibition ranged from 9.50±0.28-13.33±0.88mm and 10.67±0.67-19.00±0.58mm at concentration range of 6.25-100mg/ml. Minimum inhibitory concentrations of ethanol extract ranged from 6.25-100 mg/ml against bacterial strains. While those of aqueous extract ranged from 25-100 mg/ml against bacterial isolates. Minimum bactericidal/fungicidal concentrations of ethanol extract ranged from 25-50 mg/ml. While in the aqueous extract, value was 50 mg/ml and against bacteria. The bacterial pathogens were found to possess multiple drug resistance potential with multidrug resistance index ranging from 0.3 – 0.5. Significant difference  was  observed  between  the  treatment  and  control  groups  in  platelet  counts  (range: 95.40±1.86-126.20±5.40%  and  control:  108.60±4.19%),  PCV  (range:39.00±0.71-44.20±0.58%; control:  39.00±0.71%)  and  hemoglobin  (range:12.94±0.21-14.62±0.24  g/dl; control:  12.94±0.21 g/dl). There was no significant difference between the treatment and control groups in CD4counts (75.40±19.32-99.00±6.33cells/ml and control 75.4±19.32 cells/ml). Bryophylumpinnatumhas been shown in this work to possess both antibacterial and hematological properties.