Perceived organizational politics and turnover intention has remained to be a subject of significance in management. This study examines the direct effect between them. In addition, this study investigates whether personality (open minded, conscientious, extravert, neurotic and agreeable) moderates the politics-turnover relationship. A cross-sectional study was conducted from a sample of 210 employees working in private sector organizations from the Malaysia perception. Data was collected using self-administered report questionnaires and was analysed using multiple hierarchical regression. Consistent with the prediction, results of the study indicated that perceived organizational politics was positively related to turnover intention. Furthermore, the study finds that out of five personality traits, only open minded, conscientious and extravert moderates the relationship between perceived organizational politics and turnover intention. This research extends the current knowledge on the significance of personality traits in relation to perceived organizational politics and turnover intention among employees.