Electric stimulation can be a potential adjuvant to improve the therapeutic outcomes for the management of COVID-19. The “inflammatory reflex” as immune-inflammatory processes are modulated by the vagus nerve and vagus nerve modulation may tackle the COVID-19-associated cytokine storm. The stimulation of the vagus nerve modulates immune response through the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway, capable of inducing antiviral host factors and viral genes in the pathogenesis of severe/cases.Vagus nerve stimulation is achieved  by neuromodulatory approaches as invasive VNS (iVNS), using a specifically designed surgically implantable electrode cuff, wrapped around the cervical vagus nerve or non-invasive astranscutaneous cervical VNS (tcVNS), where the stimulating electrodes are applied to the skin surface over the sternocleidomastoid muscle in the neck, and the other, the auricular VNS, which targets the auricular branch of the vagus nerve that innervates the skin of outer ear, mainly theconcha and auditory meatus. Auricular vagus nerve modulation with SPN (auricular acupuncture using semipermanent needles (SPNs) could lead to a decrease in the host inflammatory response and SARS-COV-2replication through modulation of this NF-κBsignalling pathway. Bioelectricity regulate the immune response and stimulation of efferent vagal neurons inhibit the rise of pro-inflammatory cytokines and resulted in anti-inflammatory effects by modulation of cholinergic anti-inflammatory pathway (CAP). Nanosecond pulsed electric fields (nsPEF) induces the immune response and the neutrophil-differentiated HL-60 cells were exposed to nsPEFs, which led to release of the extracellular chromosomal DNA, and this released DNA appears to be equivalent to neutrophil extracellular traps (NETs) that serves as a host defense mechanism against the dreadful pathogens and may reduce the rate of mortality in Covid 19 cases.