Inflammation is a central part of the response to injury and infection in the immune system. It is the natural way to signalize the immune system and to restore and protect itself from foreign invaders including viruses and bacteria, which are weakened tissue. It may become problematic if the inflammatory process continues for too long, or if the inflammatory response occurs in areas not required. External infections involving the skin and wound are the most frequent complications affecting humans and animals. Medicinal plants play great roles in treatment of bacterial infections. Primary aim of the present study was to investigate the possible anti-inflammatory and antibacterial mechanism of  Malvastrum coromandelianum extract using in-vitro model. Ethyl acetate extract of Malvastrum coromandelianum was evaluated in vitro model by protein denaturation method for anti-inflammatory activity and disk diffusion method for anti bacterial activity. The ethyl acetate extract of Malvastrum coromandelianum significantly inhibited % protein denaturation as compared to standard drug and extract shows promising antibacterial activity against different bacterial species. It can be postulated from the observed results the anti inflammatory and antibacterial activity of Malvastrum coromandelianum could be due to its inhibition of protein denaturation and minimum inhibitory concentration.

Keywords: Malvastrum coromandelianum, Protein denaturation, Anti-inflammatory, Antibacterial