Background: The optimization study was conducted in an attempt to develop a non-pressurizedtopical spray of Lidocaine without propellant.

Methods: Central composite design was selected to determine the best conditions for theformulation of sprays with two independent factors were prepared (pH adjuster i.e sodium citrateand penetration enhancer i.e. propylene glycol). Concentration of propylene glycol (X1) of (5-25ml) and sodium citrate (X2) of (0.5-2.0 ml) was the value range of the variables. F5 was ideallysuited for use by spraying the container of a pump spray.

Results: The drug content of F5 was 98.8% which indicates that the drug is distributed almostuniformly throughout the formulation and that there was no loss of drug in the formulation.Evaporation time and total number of delivery of F5 batch was about 2 min and 487. Drugcontent per actuation, diffusion study of F5 and marketed formulation were 97.64, 98.88 (at 6hr)and 68.64 (at 6 hr) respectively. The best fitted model for the drug content and evaporation timewas quadric fit provided the value of r2 (0.9070 and 0.974) respectively.

Conclusion: The research work concludes about the successful preparation of non-pressurizedLidocaine spray with local anesthetic action.

Keywords: Non-pressurized Topical spray, Lidocaine, Meter dose, Actuator, High-density Polyethylene plastic bottles