The scavenger vitamin C works in lipid peroxidation, Lipid peroxidation (LPO) can be considered asAnexample of a radical chain reaction. Reactive oxygen species (ROS) produced by a diffusion ofassets, including the electron delivery chain, xanthine oxidase, myeloperoxidase and NADPHoxidase, initiate the novel reaction through abstraction of hydrogen atoms from bisallylicC–Hbonds thereby forming lipid radicals. nutrition C has the ability to defend against LPO via performingas a scavenger of ROS and by way of one-electron discount of lipid hydroperoxyl radicals thru thediet E redox cycle [Halliwell B,et al]. Antioxidant results of vitamins C and E on lipid peroxidation(LPO). The LPO chain reaction may be initiated via many radical species (indicated by means ofR•) and converts LH into The authors emphasized the important function of ascorbic acid inpreventing oxidative stress inside the developing mind in animals that, like people, can notsynthesize their personal ascorbic acid. diet C, endothelial disorder and cardiovascular sicknessimproved levels of circulating low-density lipoprotein (LDL) constitute a danger aspect for thedevelopment of cardiovascular sickness. Uptake of LDL in peripheral tissues is confined by LDLreceptors but not when LDL is oxidatively changed via LPO-derived reactive aldehydes. OxidizedLDL can be taken up with the aid of macrophages residing within the vascular wall via scavengerreceptors in an uncontrolled manner, main to accumulation of oxidized LDL and ldl cholesterol inthose vascular macrophages and to their transformation into foam cells. consequently, oxidized LDLis more atherogenic than undamaged LDL. furthermore, oxidized LDL induces cytokine production inmonocytes, facilitating their transformation into macrophages, and induces expression of mobileadhesion molecules in vascular endothelial cells, main to recruitment of monocyte-macrophages tothe vascular wall. Taken together, LPO and LDL oxidation play key roles within the early ranges ofvascular dysfunction and atherosclerosis which has turn out to be referred to as the ‘oxidativeamendment hypothesis of atherosclerosis [Steinberg D et al and NavabM,et al].
Keywords: Antioxidants, LPO, Nutrition C&E, Cardiovascular sickness, etc