Background: Acquired Protrombin Complex Deficiency (APCD) is a spontaneous hemorrhage that occurs due to decreased coagulation factor activity of vitamin K (factor II, VII, IX, and X). Other coagulation factors such as fibrinogen and platelet levels are still within normal limits. Nowadays the APCD is known as the term Vitamin K Deficiency Bleeding (VKDB) or Haemorrhagic Disease of the Newborn (HDN). Generally APCD occurs from the age of 8 days to 6 months with the highest incident occurring at the age of 3-8 weeks. Based on the age of onset, the APCD is divided into early, classical, and slow type. Incidence rate of APCD is 4 to 25 cases in 1 million births in Western countries and 25 to 80 cases per 1 million in the eastern country. The most reported cases of APCD occur in Japan and Thailand. APCD is still a frequent occurrence in times when vitamin K has been administered in newborns as a prophylactic. Many factors lead to vitamin K deficiency in newborns.

Aim: We report a case of APCD which is still common in the prophylactic era of vitamin K.

Case Report: 1). Baby aged 1 month come to IGD with a seizure complaint as much as 4x at home. Seizures occur for 30 minutes, among the seizures of unconscious patients. Mucosa lips appear pale. 2). Baby aged 2 months come with unconsciousness. The patient looked pale, without seizures and vomiting. Both patients showed the SDH picture on the brain CT-scan. Both patients do not have a history of head trauma.

Conclusion: Vitamin K deficiency in infants is caused by various factors.

Keywords: Vitamin K deficiency, Acquired Protrombin Complex Deficiency (APCD)