Inflammation is a normal response of living tissues to injury. Inflammation is a general term that indicates the local accumulation of fluid, white blood cells, and plasma proteins. Inflammation is initiated by infection, physical injury, or some local immune response. It is the normal response from the body to protect tissue and promote recovery. Inflammation is a complex process performed through the body due to many internal and external factors, in order to achieve the best control of inflammatory diseases it is mandatory to see different approaches. Using natural products is a very good example. The present study represents a comparative study with the potency of Ginger against standard ordinary Indomethacin. 4 groups of animals were used each consist of 6 animals. Representing normal group, positive group, standard group (Indomethacin) and treated group (ginger). In the Fourth group (Treated group) pre-injection of Ginger (400 mg/kg; I.P.) 1 hour prior to carrageenan injection resulted in significant decrease in the blood serum contents of (TNF-α) to 40.9 Pg / ml and also result in significant decrease in Nitric Oxide (NO) value to 35.7 µmol/g tissue. This study has shown that ginger proved a significant anti-oedematogenic and anti-inflammatory activity on hind paw edema induced by carrageenan.