The present pandemic of SARS-CoV-2 coronavirus disease 2019 (CVID-19) is particular challenge to Diabetes patients. May experience mild to more severe illnesses, organ failures, comorbidities and High risk of mortality due to pulmonary and cardiac involvement. This (descriptive-analytic) of the current study was carried out to investigate the effect of Covid-19 on patients with Diabetes in Afghan Japan Communicable Disease Hospital, Kabul, Afghanistan. We reviewed medical records of 102 patients who were hospitalized with Covid-19 between March – July in three months 2021. Data was collected on Diabetes status, Comorbid conditions and Laboratory Results. The data was analyzed using SPSS 20 (IBM). The Data analysis shows (56.86%) male with diabetes and (43.14%) female, and (70%) of patients had more than 50 years age. With high mortality rate of (49%), only (1%) patients were in normal diabetes stage. The most common conditions of died were Acute Respiratory Distress Syndrome ARDS (82%), Cardiac Pulmonary Arrest (CPA) (82%), Pneumonia (70%), Respiratory Failure (54%), Sepsis (46%), and Chronic obstructive pulmonary disease (COPD) (6%). Diabetes patients who are infected with SARS-CoV-2 are at higher risk of mortality. Our finding suggested that diabetes did not significantly impact the prognosis of Covid-19 patients but negatively affect their clinical course. Should be taken to make a significant step forward in the care for Diabetes patient. Its suggested for further research to increase patient sample size and HbA1C results.