International Conference on Biomedical and Cancer Research
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Accepted Abstracts

Association of Ki67 expression with clinicopathological parameters and molecular classification in invasive breast carcinomas.

SushmaNigudgi*: Anuradha G Patil, ShabnamKarangadan, S K Andola
Mahadevappa Rampure Medical College

Citation: Nigudgi S, Patil AG, Karangadan S, Andola SK (2019) Association of Ki67 expression with clinicopathological parameters and molecular classification in invasive breast carcinomas.. SciTech Biomed-Cancer Sciences 2019. Tokyo: Japan

Received: August 29, 2019         Accepted: August 30, 2019         Published: August 30, 2019

Abstract

Breast carcinoma is most common malignant tumour and leading cause of cancer death in women worldwide. Ki67 has a prediction of prognosis in breast carcinoma patients, and is also considered has an important biomarker in routine practice. Aim- The aim of the present study was to investigate Association of Ki67 expression with clinicopathological parameters and molecular classification in invasive breast carcinomas. Materials and Methods- A total of 100 patients diagnosed as invasive breast cancer were included in the present study. The clinical information of the patients was obtained from the institutional medical records. The expression levels of Ki67 were detected by immunohistochemical analysis. The associations between Ki67 scores and other clinicopathological parameters were evaluated. Results- The value of the Ki67 scores in all the patients was, low in 57cases(57%), intermediate in 11 cases (11%), high in 32 cases (32%) with a mean score of 33.33%.Ki67 expression was significantly associated with middle aged women, ranging from 31-50yrs (P<0.0107), ER negative status (P<0.0002), PR negative status (P<0.0038), Molecular subtype-triple negative (P<0.0024), higher Grade 3 (P<0.0106) and higher TNM Stage (P<0.0117). However association with left or right side affected, tumour size, menopausal status, lymphovascular invasion, lymph node metastasis and Her2/Neu status was not statistically significant in this study. Conclusion- In conclusion, results revealed that there is presence of significant correlations between Ki67 and otherclinicopathological parameters and molecular classification of breast cancer. Thus, Ki67 labeling index is an important prognostic and predictive member in management of breast carcinoma patients. Keywords- Invasive breast carcinoma, Ki67 Labeling Index, Clinicopathological parameters, Molecular subtypes.