International Conference on Oncology & Hematology
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Accepted Abstracts

The role of serum Il-6 and Ca-125 as a predictor of tumor resectabilities in epithelial type ovarian cancer

Andi Kurniadi* Yudi M Hidayat, Dodi Suardi, Herman Susanto, Heru Priyanto, Gatot NAW
Hasan Sadikin Hospital, Indonesia

Citation: Kurniadi A, Hidayat YM, Suardi D, Susanto H, Priyanto H et al (2019) The role of serum Il-6 and Ca-125 as a predictor of tumor resectabilities in epithelial type ovarian cancer. SciTech Immuno-Microbiology 2019. Dubai: UAE

Received: April 21, 2019         Accepted: April 22, 2019         Published: April 23, 2019

Abstract

Objective: The purpose of this study is to find out role of both serum IL-6 and CA-125 preoperative as predictor for ovarian cancer surgery resectability
Methods: The design of this study is cross sectional that is by examining patients suspected of ovarian malignancy, checking for their preoperative IL-6 and CA-125 levels and their resectability. The data obtained is recorded in a special form and then processed with SPSS version 24.0 for Windows
Resuits: Mean value of CA-125 for suboptimal cytoreduction group was higher than optimal cytoreduction (1099,75 + 1242,555 vs 311,23 + 160,165), which is statistically significant, p = 0,000 (p value <0,05), CA 125 cut off point in this research was 432 with sensitivity value of 72,2% and specificity value of 77,88%. The mean value of IL-6 for the suboptimal cytoreduced group was greater than the optimized cytoreduction (137.72 + 107.658 VS 62.20 + 66.330), which is statistically significant, p = 0.009 (p value <0.05), IL-6 cut off point at this study was 64.9 with a sensitivity of 72.2% and a specificity of 72.2 %. There was a positive correlation  between CA-125 levels and the operating outcome, p = 0.012 (p <0.05), there was a positive correlation between IL-6 levels and the operating outcome, p = 0,016 (p <0,05) and there was correlation between IL-6 and CA-125 presurgery with operating outcome (suboptimal and optimal cytoreduction) with cut off point 418,5 with sensitivity value 88.9% and specificity value 72,2% .
Conclusion: There is a correlation between the levels of serum IL-6 and CA-125 and ovarian cancer resectability.
Keywords: ovarian cancer, IL-6, CA-125, resectability, suboptimal sitoreduction and optimal sitoreduction