Received: May 29, 2019 Accepted: May 01, 2019 Published: May 02, 2019
The main objective of the present work was to develop Nanosponges loaded with 5-Flurouracil for the treatment of colon cancer. 5-Flurouracil (5-FU) has a wide anticancer activity versus several types of solid tumors. The activity of 5-FU can be improved and its toxicity can be diminished by enhancing the relative specific accumulation in the tumor regions. The potential of the drug to be incorporated into the dosage form was analyzed by preformulation studies such as FTIR study, solubility studies and the organoleptic properties. The formulation was carried out using Emulsion solvent diffusion method. In this method an organic phase consisting of the drug and polymer in dichloromethane is added to the aqueous phase consisting of PVA in water. The mixture was stirred using a magnetic stirrer at 1000rpm. The formulation was evaluated by Percentage yield, Entrapment efficiency, SEM, Zeta potential, Particle size distribution, Differential Scanning Calorimetry, In-vitro dissolution study, Porosity. The SEM images showed that the particles are spherical and nano-sized. The best formulation was selected based on the results of percentage yield, Entrapment efficiency, In-vitro dissolution study etc. The nanosponge’s prepared using 5-flurouracil are safe and effective. Nanosponges are commonly developed as a topical dosage form but this study can be used as a model to develop controlled or targeted drug delivery systems that are cheap, effective and easily affordable to the patients. This study resulted in porous nature of nanosponges which provides a channel for the release of the drug and the method is quick and reproducible. Animal studies were conducted in mice which were inoculated with Dalton ascities lymphoma cell line (2 X 106 cells per mouse) and it was found out that the prepared nanosponges were showing significant activity in a very low dose itself.