Background: Coronary heart disease remains the major cause of mortality & morbidity in the entire world population despite therapeutic advances that control many risk factors. Lipid profile is regarded as an important factor in the development of coronary heart disease(CHD). There have been numerous studies confirming the association of hyperlipidemias with CHD in most of the Western world & as well as Asian countries of the world. But we have little data on the relation between CHD & lipid profile.

Aim of the study: The aim of this study was to assess abnormal lipid levels & their association with CHD. 

Methods: A comperative observational study was conducted at the department of cardiology in M. Abdur Rahim Medical College, Dinajpur, Bangladesh from January 2019 to December 2019. Properly written consent was taken from all the participant before starting the main part of the investigation. Obeying inclusion & exclusion criteria of the study, a total 131 participant were finalized as the study population. Among Case Group was formed with 90 patients who had coronary heart disease(CHD) and with 41 healthy people, the Control Group was formed. All necessary data was collected, analyzed and disseminated by several programs of MS Office and SPSS versions 23. 

Result: The study was conducted with 90 case group participants &  41 control group participants. Among the case group 78% were male and 22% were female. The study showed serum cholesterol concentration and HDL concentration were significant between the case and control groups in all age groups and the P-value was less then 0.0001 in every age group. Triglyceride concentration was significant between Case and Control groups in 41-50 & 51-60 years age group with a P-value less then 0.0001. But in the age group more then 60 years we did not find any significant correlation and there the P-value was 0.478. LDL concentration between groups showed significant  correlation between Case and Control groups in the age groups between 41-50 & 51-60 years where P-values found less then 0.0001 and 0.0002 respectively. But in the age groups more then 60 years we did not find any significant  correlation, where the P- value was 0.515. Conclusion : In the study it was fiund that total cholesterol, LDL cholesterol, HDL cholesterol and Triglyceride were significantly higher in coronary heart disease(CHD)patients.