This cross-sectional study aimed to evaluate the post-vaccination complications of vaccines on the people around the setting of JPMC, Karachi, in Pakistan, and compare the complications of the first and second doses of COVID-19 vaccines,conducted from May 2021 to June 2022. Only vaccinated people participated in the study. This article will help spread knowledge among the general population about the common side effects of vaccination so they will not be discouraged after getting it. This research will also help spread awareness regarding vaccines' importance in eradicating the COVID-19 pandemic. We collected the data through questionnaires and by interacting with the participants. We analyzed the data through SPSS version 21 with a 95% confidence interval and significance level ( < 0.05). The total number of participants was 325, aged between 20 to 70. About 55.7% of the participants were female, while 44% were male. 28% of the participants got positive COVID tests in the past. 48.9% were medical students, 19.1% were doctors, 2.5% were pharmacists, 0.3% were nurses, and 29.2% were of other professions. About 40.3% of the participants got Sinopharm, 33% got Sinovac, 5% got Moderna, 16% got Pfizer, 4.3% got AstraZeneca, and 1.5% got Sputnik V. About 57.9% experienced minor complications after the first dose of the vaccine, and 48.3% experienced minor complications after the second dose. Among these complications, headache, fatigue, and muscle ache were statistically significant, with p-values of 0.020, 0.000, and 0.042, respectively. The study inferred that no significant health complications were reported in participants after both doses of COVID-19 vaccination, and there is a low risk of adverse effects after COVID-19 vaccination.

Abbreviations: JPMC: Jinnah Sindh Medical University; SPSS: Statistical Software for Social Sciences

Keywords: Vaccination, COVID-19, Doses, Complications of vaccines, COVID tests, Pakistan,Karachi