Global Summit on Biomedical & Cancer Research
  • Follow

Accepted Abstracts

Coeliac Disease and Diabetes in Children and Young People: Epidemiological, Clinical and Metabolic Aspects

Touzani A 1,4*, Djaffar A W1, Bennani N 3, Zineb I 1, Amhager S1 , Gaouzi A1, Filali I-M.A2, Medraoui L2,Kriouile Y1, Chabraoui L4

1CHU-Children's Hospital of Rabat University Mohamed V, Rabat
2Department of Biology, UPR-Biosafety-Biosurge, Faculty of Sciences, Rabat
3Rabat Diabetes Reference Center, Rabat
4Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine and Pharmacy, University Mohamed V, Rabat

Touzani A, Djaffar AW, Bennani N, Zineb I, Amhager S (2022) Coeliac Disease and Diabetes in Children and Young People: Epidemiological, Clinical and Metabolic Aspects. SciTech Biomed-Cancer 2022.

Received: June 07, 2022         Accepted: June 11, 2022         Published: June 11, 2022


Objectives: Our work aims to determine the prevalence of Celiac disease (CD) in Type 1 diabetic (T1D) patients and to study the impact of early detection Gluten-free diet (DFG) on metabolic control and prognosis in children and young diabetics.
Materiel and Methods: 49 DT1 of 3,000 patients had celiac disease a few years (1-6 years) after the diagnosis of diabetes, except for one patient who had CD prior to the diagnosis of T1D.
Results: The prevalence of CD is 1.6% (50/3000) in the T1D population. 14 boys and 10 girls DT1 with an average age of 14.4 years. Age of diagnosis of T1D is 4 years.  Diagnosis of CD has a median of 8.5 years. Average age of onset of CD after the diagnosis of T1D is 2.5 years. 54.5% have a moderate stature delay (-1DS, -2DS) and 4.5% have a severe stature delay (-4DS). 62.5% show normal growth after (DFG) follow-up. The major signs are common in celiac T1D: abdominal pain (57.5%), transit disorder (47.5%), abdominal swelling (45%) and cut anal mucosa (32.5%). Anti-endomysial , anti-transglutaminase and Anti-gliadin antibodies were positive in (34% , 82.6%  and in 8.9 %) respectvivelyHistological examination showed total villous atrophy (VTA) 56.4% (22/49), subtotal villous atrophy (AVST) in 10.3% (4/49), partial villus atrophy (VAS) in 28, 2% (11/49). 93% (40/43) patients comply with the DFG . The metabolic control of HbA1c that was found in patients improved by 7.9% before DFG and by 7.8% (range: 6-10, 3%) after taking the DFG. 
Conclusion In Morocco, the CD and DT1 combination is not uncommon, Gluten intolerant must be satisfied with the DFG . Strict adherence to this regimen results in reduced symptoms, recovery of the intestinal mucosa and also prevents the development of complications related to celiac disease such as cancer.
Keywords: Celiac disease , Type 1 Diabetes-Young , Prevalence ,Gluten free diet