Touzani A 1,4*, Djaffar A W1, Bennani N 3, Zineb I 1, Amhager S1 , Gaouzi A1, Filali I-M.A2, Medraoui L2,Kriouile Y1, Chabraoui L4
Received: June 07, 2022 Accepted: June 11, 2022 Published: June 11, 2022
Objectives: Our work aims to determine the prevalence of Celiac disease (CD) in Type 1 diabetic (T1D) patients and to study the impact of early detection Gluten-free diet (DFG) on metabolic control and prognosis in children and young diabetics.
Materiel and Methods: 49 DT1 of 3,000 patients had celiac disease a few years (1-6 years) after the diagnosis of diabetes, except for one patient who had CD prior to the diagnosis of T1D.
Results: The prevalence of CD is 1.6% (50/3000) in the T1D population. 14 boys and 10 girls DT1 with an average age of 14.4 years. Age of diagnosis of T1D is 4 years. Diagnosis of CD has a median of 8.5 years. Average age of onset of CD after the diagnosis of T1D is 2.5 years. 54.5% have a moderate stature delay (-1DS, -2DS) and 4.5% have a severe stature delay (-4DS). 62.5% show normal growth after (DFG) follow-up. The major signs are common in celiac T1D: abdominal pain (57.5%), transit disorder (47.5%), abdominal swelling (45%) and cut anal mucosa (32.5%). Anti-endomysial , anti-transglutaminase and Anti-gliadin antibodies were positive in (34% , 82.6% and in 8.9 %) respectvivelyHistological examination showed total villous atrophy (VTA) 56.4% (22/49), subtotal villous atrophy (AVST) in 10.3% (4/49), partial villus atrophy (VAS) in 28, 2% (11/49). 93% (40/43) patients comply with the DFG . The metabolic control of HbA1c that was found in patients improved by 7.9% before DFG and by 7.8% (range: 6-10, 3%) after taking the DFG.
Conclusion In Morocco, the CD and DT1 combination is not uncommon, Gluten intolerant must be satisfied with the DFG . Strict adherence to this regimen results in reduced symptoms, recovery of the intestinal mucosa and also prevents the development of complications related to celiac disease such as cancer.
Keywords: Celiac disease , Type 1 Diabetes-Young , Prevalence ,Gluten free diet