The COVID-19 till date has groped in around million lives across the globe that includes children and elderly who became a victim of this pandemic. During course of this pandemic, there has been discussion of age related vulnerability to the disease and the preventive measures and policies implemented by various countries across the globe. The elderly have suffered a disproportionate burden of COVID-19. Patients associated co-morbidities pose a greater threat to that group as compared to general population. The epidemiological data and Case Fatality Ratio (CFR) collected from countries vary significantly but give a vivid picture of the situation of the pandemic in each region. Hence, the author reviewed the published data from several countries to investigate relationship between age and COVID- 19 mortality and morbidity. The author also took the time to study briefly about the role of angiotensin converting enzyme 2 (ACE2) as a receptor against the new coronavirus SARS-CoV-2. The author also reviewed the literature for studies explaining the difference in the physiological inflammatory response to SARS-CoV-2 infection according to age.
Thus, the information achieved from these data will prove to be useful in determining the precautionary and preventive policies irrational treatment of COVID-19.
Keywords- SARS-CoV-2, Pandemic, ACE2, Age, Morbidity, Mortality, Comorbidities