Pharmacology & Drug Development Congress
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Accepted Abstracts

A Comparative Study of Epidural Tramadol With Epidural Pentazocine for Postoperative Analgesia in Patients Undergoing Lower Abdominal Surgeries

Yadhuraj MK*
Kidwai Cancer Institute, India

Citation: Yadhuraj MK (2020) A Comparative Study of Epidural Tramadol With Epidural Pentazocine for Postoperative Analgesia in Patients Undergoing Lower Abdominal Surgeries. SciTech Central Pharma 2020. Mauritius

Received: October 31, 2019         Accepted: November 05, 2019         Published: November 05, 2019

Abstract

Objectives
 
To evaluate and compare the efficacy of epidurally administered Tramadol  Hydrochloride and Pentazocine Lactate in providing post operative pain relief for
lower abdominal and lower limb surgeries.
 
To compare the side effects between epidural tramadol and pentazocine.
 
Design
A prospective randomized study
 
Methodology
 
The study population consisted of 100 patients aged between 18-65 years posted for various elective lower abdominal and lower limb surgeries requiring neuraxial anaesthesia at M.V.J.Medical College & Research Hospital, Hoskote, Bangalore.  The study population was randomly divided into 2 groups with 50 patients in each sub group.
 
  1. Group T: Administered 50mg Tramadol, diluted to 10ml with Normal saline, epidurally  (n= 50)
  2. Group P: Administered 0.3mg/kg Pentazocine, diluted to 10ml with Normal saline,
epidurally (n = 50)
Patient was monitored on various parameters including duration of action, hemodynamic variables, and side effects
 
Results : 
 
In group administered 50mg Tramadol epidurally, the mean time to onset of analgesia was 4.36±2.23 mins and the mean time to onset of analgesia in the group administered pentazocine was 4.84±2.24 mins, with a p value of 0.286, which is not considered significant. In tramadol group, the analgesic period averaged 7 hours 20 minutes, while the duration of analgesia in group P averaged 6 hours 43 minutes, with a p value of 0.475, which is not considered significant. It was also observed that 0.3mg/kg of pentazocine produced marginally higher incidence of bradycardia, dizziness, drowsiness and sedation as compared to 50mg of tramadol on epidural administration.
 
 Conclusion : 
 
With these results, we conclude that epidural tramadol 50mg gives longer lasting and more profound analgesia with lesser side effects when compared to 0.3mg/kg of pentazocine.
 
Keywords:
 
Post operative analgesia, epidural anaesthesia, Tramadol, Pentazocine, Visual analog score.