Pharmacology & Drug Development Congress
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Accepted Abstracts

Yeast Sludge Components and Whey Powder Ameliorate Cchratoxin A Induced Toxicity

Huma Mujahid1*, Abu Saeed Hashmi2, Muhammad Zargham Khan3, Wasim Shehzad1, Muhammad Tayyab1

1 University of Veterinary and Animal Sciences, Lahore
Riphah College of Veterinary Medicine, Lahore
3 University of Agriculture, Faisalabad

Citation: Mujahid H, Hashmi AS, Khan MZ, Shehzad W, Tayyab M (2020) Yeast Sludge Components and Whey Powder Ameliorate Cchratoxin A Induced Toxicity. SciTech Central Pharma 2020

Received: November 07, 2019         Accepted: November 11, 2019         Published: November 11, 2019

Abstract

OTA is fungal secondary metabolite produced by several toxigenic fungal strains of Aspergillus and Penicillium. Aspergillus ochraceus is the top most specie of ochratoxin –producing fungi. Ochratoxin A has nephrotoxic, neurotoxic, mutagenic, immunosuppressive, hepatotoxic and teratogenic properties in several species of animals and carcinogenic property in mice and rats. In addition human exposure is also a potential threat, since the presence of OTA in blood and breast milk has been detected, and it has also been linked to fatal kidney diseases referred to as Balkan endemic nephropathy. Yeast sludge and whey are produced in bulk quantities by alcohol production Industry and Dairy Industry. These waste materials are not only nutritionally beneficial but they also have the potential to detoxify ochratoxin A. Day old broilers birds (n=1750) were randomly divided into seven groups replicated five times in such a way that each replicate has 50 birds. Group A (Normal poultry Feed), B (ochratoxin A 200ppb), C (200ppb ochratoxin A and 0.2% dried yeast sludge),D (200ppb Ochratoxin A and 0.2% yeast sludge cell mass), E (200ppb Ochratoxin A and 0.2% yeast sludge cell wall) F (200ppb Ochratoxin A and 0.2% whey powder) and group G (200ppb Ochratoxin A and 0.2% protemyc a commercial mycotoxin binder). Ochratoxin A negatively affects body weight gain, feed consumption and FCR. Haematobiochemical parameters such as ALT, AST, serum total protein, albumin, globulin and creatinin were also found to be altered. However, supplementation of yeast sludge, yeast sludge cell mass, yeast sludge cell wall and whey in feed has reduced the toxic effects of ochratoxin A.
 
Keywords: Ochratoxin A, Yeast sludge, Whey, Haematobiochemical parameters