Objective: To investigate changes in prostaglandin E2, IL-6, and IL-10 levels in patients with SIRS that affect pain intensity change.

Methods: This research is cross sectional analysis to compare the values of PGE2, IL-6 IL-10, PPT, and CPOT of patients with and without SIRS.

Results: Of the 46 patients who were the subjects of the study, there were 21 SIRS patients and 25 patients not SIRS. Patients with SIRS had higher CPOT values and PGE2 levels than patients without SIRS; CPOT values (3.3 vs 1.2)) and PGE2 levels (6195.81 vs 2728.67). Unlike the value of PPT; The PPT scores of patients with SIRS were lower than those without SIRS (4.24 vs 7.37). The CPOT was only significantly correlated (p <0.05) with PGE2 (r = -0.624). IL-6 was only significantly correlated (p <0.05) with PGE2 (r = -0.846).

Conclusions: In SIRS patients there is an increase in proinflammatory (IL-6) cytokines that has an effect on the increase of PGE2, which in turn leads to increased pain intensity (CPOT) and decreased pain threshold (PPT).

Keywords : SIRS (systemic inflammatory response syndromes), CPOT (critical care pain observation tools), PPT (Pain Pressure Threshold), IL-6 (Interleukin-6), IL-10 (interleukin-10), PGE2 (prostaglandin E2).