Abdominal obesity usually associate with condition of insulin resistance and hyperinsulinemia. Numerous studies have found that prevalence of benign prostatic hyperplasia (BPH) was higher in abdominal obesity. This study was aimed to evaluated that abdominal obesity patient with high level of HOMA-IR, IGF-1, IL-6 and hsCRP have higher risk of BPH, compared thanAbdominal obesity patients with low level of HOMA-IR, IGF- 1, IL-6 and hsCRP, and to investigate wether insulin resistance and high level of IGF-1, IL-6 and hsCRP as risk factor of BPH in Abdominal obesity patients. The study design wascase control. Eighty patients were involved in this study, fourthly male central obesity subject with Prostate hyperplasia as case group and fourthly male Abdominal obesity without prostatic BPH, with age more than 40 years old both case and control. Data analysis were done by student t test, chi square, multivariate logistic regression analysis and completed by path analysis to measure the effect of each risk factor. Measurementof IGF-1 with Immulite 2000 IGF-1method with chemiluminescent immunometri assay, IL-6 was measured with sandwich enzyme immunoassay with Quantikine immunoassay kit, production of R&D system Inc USA, and hsCRP was measured with immonometric assay. Fasting blood glucose (Z=-3,325, p=0,001), Fasting insulin level (Z=-2,15, p=0,034), HOMA-IR (Z=-2,843, p=0,004), and 4 IGF-1 (t=3,27, p=0,002) of case group was higher and statisticaly significant compared to control group. hsCRP and IL-6 not significantly different between case and control groups. Analysis bivariatechi-square test, found that the insulin resistance (HOMA- IR) (OR=1,68, p=0,019) and IGF-1 (OR=2,14, p=0,001) were associate with Prostatic hyperplasia in Abdominal obesity patients. Finally we found that insulin resistance/HOMA-IR (OR:2,59 IK(0,88-7,02), p=0,043) and high level of IGF-1 (OR:4,76, IK (1,71-13,11), p=0,003) as a risk factors of BPH in Abdomin obesity patients. Path analysis show us that significantly correlation between HOMA-IR with IGF-1 (CR=4,61; p<0,001), HOMA-IR with prostate hyperplasia (CR3,64; p<0,001), IGF1 with prostate hyperplasia (CR=3,19; p<0,001) It was concluded that HOMA-IR (insulin resistance) and high level of IGF-1 as risk factors of Prostate hyperplasiain Abdominal obesity. Key Words: HOMA-IR, IGF-1, Abdominal obesity, prostatic hyperplasia.