A number of plant derived compounds and phytochemicals from medicinal herbs are involved in anti-angiogenesis activity. Angiogenesis is a natural process that functions in formation of new and repairing of damaged blood vessels. A series of chemicals are involved in stimulation and inhibition of this phenomena. Vascular endothelial growth factor receptors (VEGF) are involved in angiogenesis through a cascade of signaling pathways. This review targets to summarize a list of medicinal herbs and plant compounds, which are part of current research for the development of anti-cancerous agents and anti-angiogenesis compounds. Angiogenesis is also related to diseases including endometriosis, inflammation, tumor formation and diabetic nephropathy. A number of anti-angiogenic compounds for VEFG-2, MetAP-2 (methionine amiopeptidase-2) are present with minimal toxic side effects. Quercetin, Genistein, cinnamic acid, flavone, iso-flavanol and phenolic compounds naturally present in plants have been reported as angiogenesis inhibitors. This review will help in detailed and timely addition to the literature of medicinal research.
Keywords: Medicinal plants, anti-angiogenesis, phytochemicals, treatment