World Congress on Immunology & Microbiology
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Accepted Abstracts

Screening of endophytic fungi stored in culture collection for taxol production

Maria Betânia Melo de Oliveira*
Universidade Federal de Pernambuco, Brazil

Citation: Melo de Oliveira MB (2019) Screening of endophytic fungi stored in culture collection for taxol production. SciTech Immuno-Microbiology 2019. Dubai: UAE

Received: February 07, 2019         Accepted: February 08, 2019         Published: February 09, 2019

Abstract

Endophytic microorganisms are those that  live  inside plants, inhabiting the aerial parts, such as the leaves and stems, without causing any damage to their hosts, unlike pathogens. These fungi may present many applications, such as use  in  bioremediation,  processes and  production  of compounds with antimicrobial, antioxidant or antitumor activities.  However, still been poorly explored industrially. According to the World Health Organization (WHO), 8.8 million deaths occurred in 2015, due to cancer, and it is estimated that 12.6 million deaths will occur per year by 2030. Taxol (paclitaxel) is a potent drug used in the treatment of some neoplasms, as both a first – and second – line of treatment. It acts by inhibiting cell replication through binding to the beta-tubulin subunit of microtubules and induces apoptosis by inactivating the apoptosis inhibitory protein Bcl-2. Taxol can also be produced by some fungi. This study performed a screening to characterize endophytic fungi in a culture collection  with ability to produce taxol through a search of the genes involved in the taxol metabolic pathway. This work shows the biotechnological potential of an isolate of this collection as producer of  taxol, a substance with high pharmacological relevance and discuss alternatives to facilitate the industrial use of this drug in antitumor activities.